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. Author manuscript; available in PMC: 2022 Apr 22.
Published in final edited form as: J Physiol. 2021 Sep 29;600(4):903–919. doi: 10.1113/JP281902

Figure 1. Metformin given to the obese mum during pregnancy can reach the fetal circulation and fetal tissues.

Figure 1

(A) Metformin concentrations measured in maternal serum were correlated with fetal plasma concentrations and (B) metformin levels in the placenta, circles represent female, triangles represent male fetuses. Linear regression and Pearson correlation coefficient r are shown. (C) Expression of eleven transporters (known for their ability to transport metformin) was analysed in E18.5 placenta, fetal liver and fetal kidney, n=3 per tissue type and sex respectively. Raw CT values are shown, ranging from high expression (low CT values, red color) to low expression (high CT values, blue color) and Sdha included as an endogenous control. (D) Metformin was measured in fetal kidney, liver, amniotic fluid (n=3 female and n=3 male) and placentas (n=7 male, n=6 female) via LC-MS, fluid samples are expressed in nmol/mL and tissue samples in nmol/g to allow an approximate comparison.