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. Author manuscript; available in PMC: 2022 Apr 22.
Published in final edited form as: Sci Signal. 2022 Apr 5;15(728):eabj6915. doi: 10.1126/scisignal.abj6915

Fig. 8. Graphical summary.

Fig. 8

Candidalysin is secreted into an invasion pocket formed by C. albicans hyphae. Candidalysin intercalates into the host cell membrane and stimulates the release of EGFR ligands, which induces ERK1/2 activation downstream of EGFR, resulting in c-Fos activation and the release of the neutrophil-activating chemokines GM-CSF and G-CSF. Through a parallel pathway, candidalysin also activates p38, resulting in IL-6 release and Hsp27 phosphorylation. p38 activation is not triggered by EGFR but by two selective and independent pathways that differentially control p38 signaling outputs. MKK3/6 promote IL-6 release, whereas Src triggers p38-induced EGFR phosphorylation independent of ligand binding. Both Src and MKK3/6 promote p38-dependent Hap27 phosphorylation. Created with BioRender.com