TABLE 2.

Sample sizes and empirical power (%) for $n=n_C=n_T$ for the co‐primary, multiple primary, and composite endpoints for overall power $1-\beta \approx 0.80$, $\alpha =0.025$, $k_m=2,K=4$ with observed and latent effect sizes ${\delta }_1,{\delta }_2,{\delta }_3^{\ast },{\delta }_4^{\ast }$ and correlation $\mathit{\rho }$ equal to 0.3, 0.5, 0.8 where correlations are assumed to be equal between all endpoints

${\delta }_1$	${\delta }_2$	${\delta }_3^{\ast }$	${\delta }_4^{\ast }$	$\mathit{\rho }$	Co‐primary	Multiple primary	Composite
0.12	0.12	0.12	0.12	0.0	1766 (80.1)	591 (80.0)	1031 (80.1)
				0.3	1692 (80.0)	744 (80.1)	883 (80.0)
				0.5	1617 (80.0)	867 (80.1)	687 (80.0)
				0.8	1439 (80.0)	1117 (80.0)	589 (79.9)
0.35	0.35	0.15	0.15	0.0	917 (79.9)	105 (80.1)	201 (79.9)
				0.3	894 (80.0)	122 (79.9)	156 (80.0)
				0.5	870 (80.0)	134 (80.0)	115 (80.1)
				0.8	815 (80.1)	153 (80.0)	92 (80.0)
0.12	0.35	0.55	0.10	0.0	1772 (80.2)	61 (80.3)	81 (80.0)
				0.3	1736 (80.2)	67 (80.5)	72 (80.1)
				0.5	1700 (80.0)	70 (79.9)	67 (80.2)
				0.8	1625 (80.2)	74 (80.6)	58 (80.1)