Table 2. The association of metabolic health status and its components with fecundability (n=834).
| Metabolic health indicators | n | Pregnancies | Cycles | Crude | Model 1a | Model 2b |
|---|---|---|---|---|---|---|
| FR (95% CI) | FR (95% CI) | FR (95% CI) | ||||
| Metabolic health status | ||||||
| MetS criteria ≥3 | 85 | 14 | 190 | 0.34 (0.20, 0.58) | 0.38 (0.22, 0.65) | 0.36 (0.21, 0.63) |
| HOMA-IR ≥2.5 | 123 | 28 | 290 | 0.47 (0.32, 0.69) | 0.48 (0.32, 0.72) | 0.39 (0.25, 0.62) |
| Metabolic components | ||||||
| High waist circumference (≥80 cm) | 510 | 200 | 1668 | 0.79 (0.65, 0.97) | 0.88 (0.71, 1.11) | 0.94 (0.73, 1.21) |
| Raised triglyceride (≥1.7 mmol/L) | 61 | 11 | 161 | 0.37 (0.20, 0.68) | 0.42 (0.23, 0.77) | 0.42 (0.23, 0.78) |
| Reduced HDL-C (<1.3 mmol/L) | 309 | 117 | 1003 | 0.81 (0.65, 1.01) | 0.85 (0.68, 1.08) | 0.88 (0.68, 1.12) |
| Raised fasting glucose (≥5.6 mmol/L) | 38 | 6 | 47 | 0.37 (0.16, 0.82) | 0.44 (0.19, 0.98) | 0.45 (0.20, 1.03) |
| Raised blood pressure (≥130/85 mmHg) | 36 | 8 | 77 | 0.49 (0.24, 0.99) | 0.56 (0.28, 1.13) | 0.57 (0.28, 1.17) |
| Presence of metabolic risk markers | ||||||
| 0 | 252 | 126 | 1106 | Ref. | Ref. | Ref. |
| 1 | 319 | 153 | 1192 | 0.98 (0.77, 1.24) | 1.06 (0.84, 1.35) | 1.08 (0.83, 1.38) |
| 2 | 178 | 72 | 572 | 0.84 (0.63, 1.13) | 0.94 (0.70, 1.28) | 0.91 (0.64, 1.29) |
| 3 | 63 | 11 | 140 | 0.33 (0.18, 0.62) | 0.38 (0.20, 0.70) | 0.35 (0.18, 0.69) |
| ≥4 | 22 | 3 | 50 | 0.29 (0.09, 0.90) | 0.39 (0.12, 1.23) | 0.35 (0.11, 1.15) |
Data were analysed using discrete-time proportional hazards models. CI, confidence interval; FR, fecundability odds ratio; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment-insulin resistance; MetS, metabolic syndrome.
a
Model 1: adjusted for age, ethnicity, education, physical activity, smoking exposure and alcohol intake.
b
Model 2: adjusted for Model 1 + body mass index.