Skip to main content
. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Science. 2022 Apr 14;376(6595):844–852. doi: 10.1126/science.abn3810

Figure 5. Structure of the complete CCAN-CENP-A inner kinetochore module.

Figure 5

(A) Atomic model of the CCAN-CENP-ANuc complex. (B) Cartoon schematic of the CCAN-CENP-ANuc complex. (C) Mutations of CENP-N and CENP-TW previously shown to impair centromere function contribute to the DNA-binding channel of the CCAN (4, 7–9). Residues implicated in DNA binding by CENP-L, and mutated in the current study, are also shown.