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. 2022 Feb 22;71(5):1115–1127. doi: 10.2337/db21-1166

Figure 3.

Figure 3

Ap2-Cre expression results in Gipr knockdown in adipose and brain tissues. A) Gipr expression in adipose depots and brain tissues. (n = 4). B) Body weights (BWs) in 8-week-old mice prior to initiation of HFD feeding (n = 7–11). Absolute (C) and percentage increases (D) in BWs of mice fed a 45% HFD for several weeks (n = 7–11). E) Body composition expressed as a percentage of total (left) or absolute (right) weight in mice after 16 weeks of HFD feeding (n = 8–11). F) Blood glucose levels and area under the glucose curve (AUC) during an oral glucose tolerance test (OGTT) after 17 weeks of HFD feeding (n = 10–12). G) Blood glucose levels during an insulin tolerance test (ITT) after 6 weeks of HFD feeding (n = 10–12). H) Oxygen consumption after 20 weeks of HFD feeding (n = 8). I) Food intake (24 h) after 20 weeks of HFD feeding (n = 8). J) Tissues weights after 20 weeks of HFD feeding (n = 7–10). A) For relative mRNA expression, values were normalized to levels detected in RNA isolated from the same adipose tissue depots of Ap2-Cre mice. *P < 0.05 vs. control.