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. Author manuscript; available in PMC: 2022 Jun 2.
Published in final edited form as: Nat Med. 2021 Feb 22;27(3):491–503. doi: 10.1038/s41591-021-01232-w

Extended Data Fig. 4. Differential expression and functional enrichment analyses comparing NDMM and PRMM patients.

Extended Data Fig. 4

a, Volcano plot showing a selected set of differential genes between NDMM and PRMM patients. X axis showing the difference between the average z-score of NDMM patients and PRMM patients; Y axis showing the -log10 p-value from a bootstrap test using t-statistic (Methods). b, Heat map showing the correlation map of all the differential genes identified between the NDMM and PRMM patients. Genes are clustered using hierarchical clustering. c, Functional enrichment of the 3 gene modules using Metascape. d, Graphical illustration of non-responder overall PI resistant pathway.