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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Development. 2022 Jun 10;149(11):dev186536. doi: 10.1242/dev.186536

Fig. 2. Linear distance influences enhancer-gene regulatory specificity.

Fig. 2

The responsiveness of different promoter types to enhancers can depend on linear distance. The promoters of housekeeping (HK) genes (top) are normally activated by proximal regulatory elements and show low responsiveness to proximal or distal enhancers. Tissue-specific (TS) genes (middle) also show low responsiveness to distal enhancers, but high responsiveness to proximal enhancers. In contrast, developmental genes (DEV; bottom) show high responsiveness to distal enhancers.