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. Author manuscript; available in PMC: 2022 Jun 30.
Published in final edited form as: Nat Genet. 2021 Jan 7;53(1):54–64. doi: 10.1038/s41588-020-00751-5

Figure 1.

Figure 1

A Sample size by contributing study and technique for each of the 174 metabolites included. B A three-dimensional Manhattan plot displaying chromosomal position (x-axis) of significant associations (p <4.9×10-10, z-axis) across all metabolites (y-axis). Colours indicate metabolite groups. C A top view of the 3D-Manhattan plot. Dots indicate significantly associated loci. Colours indicate novelty of metabolite – locus associations. Loci with indication for pleiotropy have been annotated.