Table 1. Genomic loci with effect sizes larger than 0.25 units in standard deviation of metabolite levels per allele.
| rsID | Position* | Metabolite | EA/OA | EAF | N | MA p-value | Beta (se)** | Candidate genes | Expl. var. (%) |
|---|---|---|---|---|---|---|---|---|---|
| rs13538 | 2:73868328 | Acetylornithine | A/G | 0.78 | 30692 | 1.99E-1984 | 0.85 (0.01) | NAT8, ACTG2 | 18.4 |
| rs3916 | 12:121177272 | Butyrylcarnitine | C/G | 0.26 | 30694 | 1.67E-2010 | 0.81 (0.01) | ACADS, | 16.9 |
| rs12587599 | 14:104575130 | Asparagine | T/C | 0.14 | 23606 | 8.98E-294 | 0.49 (0.013) | ASPG, ADSSL1 | 8.2 |
| rs3970551 | 22:18906839 | Proline | G/A | 0.11 | 23618 | 1.10E-224 | 0.48 (0.015) | PRODH | 5.0 |
| rs174547 | 11:61570783 | lysoPC a C20:4 | T/C | 0.67 | 16829 | 4.42E-398 | 0.47 (0.015) | FADS1, DAGLA | 9.9 |
| rs174545 | 11:61569306 | PC aa C38:4 | C/G | 0.67 | 16828 | 1.37E-361 | 0.45 (0.015) | FADS1, | 9.2 |
| rs715 | 2:211543055 | Glycine | C/T | 0.31 | 80000 | 3.00E-1632 | 0.44 (0.006) | CPS1, IDH1 | 12.9 |
| rs174564 | 11:61588305 | PC ae C42:3 | A/G | 0.66 | 9363 | 5.72E-183 | 0.44 (0.015) | FADS1, DAGLA | 8.9 |
| rs174547 | 11:61570783 | PC aa C36:4 | T/C | 0.67 | 16830 | 3.25e-313 | 0.43 (0.015) | FADS1, DAGLA | 8.6 |
| rs1171617 | 10:61467182 | Carnitine | T/G | 0.77 | 31001 | 2.06E-444 | 0.43 (0.011) | SLC16A9, | 7.0 |
| rs102275 | 11:61557803 | PC ae C40:5 | T/C | 0.67 | 16839 | 8.23E-202 | 0.43 (0.015) | C11orf10, DAGLA | 8.7 |
| rs7157785 | 14:64235556 | PC aa C28:1 | T/G | 0.16 | 16833 | 4.60E-136 | 0.35 (0.019) | SGPP1,SYNE2 | 3.3 |
| rs174547 | 11:61570783 | PC ae C36:5 | T/C | 0.67 | 16828 | 2.48E-185 | 0.33 (0.015) | FADS1, DAGLA | 5.1 |
| rs102275 | 11:61557803 | PC aa C38:5 | T/C | 0.67 | 16836 | 8.31E-198 | 0.33 (0.015) | C11orf10, DAGLA | 5.0 |
| rs174564 | 11:61588305 | PC ae C42:2 | A/G | 0.66 | 9363 | 7.04E-99 | 0.32 (0.015) | FADS1, DAGLA | 4.8 |
| rs174564 | 11:61588305 | lysoPC a C26:1 | A/G | 0.66 | 9363 | 1.38E-91 | 0.32 (0.016) | FADS1, DAGLA | 4.6 |
| rs7157785 | 14:64235556 | SM (OH) C14:1 | T/G | 0.16 | 16833 | 1.65E-96 | 0.29 (0.019) | SGPP1 | 2.2 |
| rs174546 | 11:61569830 | PC aa C24:0 | C/T | 0.67 | 13184 | 4.16E-89 | 0.29 (0.016) | FADS1, DAGLA | 3.6 |
| rs174546 | 11:61569830 | PC ae C38:5 | C/T | 0.67 | 16839 | 8.98E-146 | 0.29 (0.015) | FADS1, DAGLA | 3.9 |
| rs7552404 | 1:76135946 | Octanoylcarnitine | A/G | 0.69 | 31969 | 2.30E-260 | 0.28 (0.01) | ACADM | 2.8 |
| rs1171615 | 10:61469090 | Propionylcarnitine | T/C | 0.77 | 32590 | 7.09E-185 | 0.27 (0.011) | SLC16A9 | 3.1 |
| rs1171617 | 10:61467182 | Acetylcarnitine | T/G | 0.77 | 31008 | 1.92E-156 | 0.27 (0.011) | SLC16A9 | 3.3 |
| rs2286963 | 2:211060050 | Nonaylcarnitine | G/T | 0.36 | 13925 | 5.46E-159 | 0.26 (0.016) | ACADL | 3.2 |
| rs12210538 | 6:110760008 | Octadecandienylcarnitine | A/G | 0.77 | 30227 | 1.69E-144 | 0.26 (0.011) | SLC22A16 | 1.0 |
| rs102275 | 11:61557803 | PC aa C36:5 | T/C | 0.66 | 16835 | 2.09E-120 | 0.25 (0.015) | C11orf10, DAGLA | 3.0 |
| rs174550 | 11:61571478 | PC ae C36:3 | C/T | 0.33 | 16830 | 2.05E-105 | 0.25 (0.015) | FADS1, DAGLA | 2.7 |
EA = effect allele; OA = other allele; MA = meta-analysis; se = standard error
*Chromosome:Position based on Genome Reference Consortium Human Build 37
**based on meta-analysis across cohorts for which individual-level data was available (more information is provided in Supplementary Tab. S).