Table 2. Results from Mendelian randomisation (MR) analysis between metabolite levels and risk of macular telangiectasia type 2.
Metabolite | Univariable MR | Multivariable MR |
---|---|---|
Serine (4 SNPs) | ||
Odds ratio per SD increase | 0.06 (0.03; 0.13) | 0.10 (0.05; 0.21) |
p-value | 9.45x10-12 | 2.95x10-9 |
Glycine (15 SNPs) | ||
Odds ratio per SD increase | 0.17 (0.08; 0.37) | 0.50 (0.29; 0.87) |
p-value | 9.99x10-6 | 1.35x10-2 |
MR estimates are based on the inverse variance-weighted method using random effects to pool estimates. All single nucleotide polymorphisms (SNPs) significantly associated with either serine or glycine have been included in multivariable MR analysis. SD = standard deviation