. Author manuscript; available in PMC: 2022 Jun 30.

Published in final edited form as: Nat Genet. 2021 Jan 7;53(1):54–64. doi: 10.1038/s41588-020-00751-5

Table 2. Results from Mendelian randomisation (MR) analysis between metabolite levels and risk of macular telangiectasia type 2.

Metabolite	Univariable MR	Multivariable MR
Serine (4 SNPs)
Odds ratio per SD increase	0.06 (0.03; 0.13)	0.10 (0.05; 0.21)
p-value	9.45x10^-12	2.95x10^-9
Glycine (15 SNPs)
Odds ratio per SD increase	0.17 (0.08; 0.37)	0.50 (0.29; 0.87)
p-value	9.99x10^-6	1.35x10^-2

MR estimates are based on the inverse variance-weighted method using random effects to pool estimates. All single nucleotide polymorphisms (SNPs) significantly associated with either serine or glycine have been included in multivariable MR analysis. SD = standard deviation