Mx-Cre+;FoxO1/3/4l/l
|
– |
|
Expansion of myeloid lineage and decrease in lymphoid commitment
Loss of stem cell population in bone marrow
Increased ROS levels in HSCs
|
47 |
FoxO3a–/–
|
– |
|
|
46 |
Atm–/–
|
By 24 weeks, post BM failure |
|
|
43 |
Mx1-Cre-;Pdk2,4–/–
|
– |
|
Loss of quiescence in HSCs and steady state hematopoiesis affected
Accumulated mitochondrial ROS and diminished repopulation capacity
Multilineage engraftment capacity remained unaffected
|
5 |
Mx-1-Cre;Tscfl/fl
|
– |
Increase in the size and number of erythroid, macrophage, megakaryocyte and granulocyte colonies
Increase in percentage of apoptotic cells in the aforesaid colonies
|
Increased mitochondrial biogenesis, increased mitochondrial DNA expression, increased ROS
Active cycling of HSCs and loss of transplantation potential
Premature aging of the hematopoietic system
|
52 |
Sirt7–/–
|
– |
Not mentioned |
Increased mitochondrial mass and ATP levels in HSC, increased mitochondrial function
Loss of hematopoietic function
|
50 |
Vav1-Cre;Mtch2fl/fl
|
– |
|
Increased mitochondrial pathways in HSCs, increase in size and activity of mitochondria
Increased HSC entry into cell cycle, decreased frequency of primitive HSCs
|
6 |
Mx1-Cre;HIF1afl/fl
|
– |
– |
|
4 |
Germline Rev1–/–
|
Lifespan shorter than WT littermates |
|
|
79 |
Rev1–/– Xpc–/–
|
≈3.5 months |
– |
Embryos born in sub-Mendelian ratios
Smaller embryos than WT or single deficient littermates
Major hematopoietic defects; very less HSC numbers starting as early as E14 FL
Increased HSC cycling
|
79 |