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. 2022 Apr 10;28(13):2911–2922. doi: 10.1158/1078-0432.CCR-21-1643

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©2022 The Authors; Published by the American Association for Cancer Research

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Figure 5. Relationship between signature exposures and clinical factors. A, Unsupervised hierarchical clustering in combined early-stage and late-stage cohorts. B, Distributions of CN signature exposures in three clusters. C, Early-stage and late-stage samples by cluster; chi-square test. D, Overall survival by cluster. Log-rank for trend. E, Forest plot of HR estimates on overall survival (OS) for clusters. Cox proportional hazards. — Relationship between signature exposures and clinical factors. A, Unsupervised hierarchical clustering in combined early-stage and late-stage cohorts. B, Distributions of CN signature exposures in three clusters. C, Early-stage and late-stage samples by cluster; chi-square test. D, Overall survival by cluster. Log-rank for trend. E, Forest plot of HR estimates on overall survival (OS) for clusters. Cox proportional hazards.