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. Author manuscript; available in PMC: 2022 Jul 5.
Published in final edited form as: Nat Med. 2021 Apr 9;27(4):668–676. doi: 10.1038/s41591-021-01310-z

Figure 1. Outline of the analyses performed.

Figure 1

Using multiple data sources, this study tested cis-pQTL and cis-eQTL proposed instruments for actionable druggable proteins against COVID-19 hospitalization summary statistics meta-analyzed from the Host Genetics Initiative and the Million Veteran Program. Significant MR associations that also showed evidence for colocalization were investigated further with an independent platform (Olink), phenome-wide scans of relevant variants, and pathway enrichment.