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. Author manuscript; available in PMC: 2022 Jul 20.
Published in final edited form as: Neuropharmacology. 2018 Mar 2;135:1–10. doi: 10.1016/j.neuropharm.2018.02.025

Fig. 4. Long term TLR3 activation significantly reduces frequency and amplitude of mEPSCs and surface AMPAR expression.

Fig. 4

A + B) Representative traces displaying mEPSCs in the absence and presence of poly I:C (25μg/ml, 1h). C + D) Bar charts revealing no effects of poly I:C (25μg/ml, 1h) on mEPSC frequency and amplitude respectively. E) Representative images and bar chart revealing the effects of poly I:C (25μg/ml, 1h) on AMPAR surface expression. F) Representative blots and bar chart revealing the effects of poly I:C (25μg/ml, 1h) on AMPAR and caspase 3 protein expression. ***P < 0.001. Data are mean ± S.E.M, with n≥7 for each data set taken from at least 3 different cultures. Scale bar = 20μm.