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. Author manuscript; available in PMC: 2022 Jul 17.
Published in final edited form as: J Hepatol. 2018 Sep 8;70(1):40–49. doi: 10.1016/j.jhep.2018.08.021

Fig. 4. Contrast agent inflow in CSF filled compartments (aqueduct, lateral ventricles and third ventricle) and volumes of select brain regions are not altered in HE.

Fig. 4

Intensity (% change from baseline) vs. time plots of contrast agent penetration indicating no difference between sham-operated (n = 5) and BDL (n = 5) rats in the (A) aqueduct, (B) lateral ventricles and (C) 3rd ventricle. Grey shading indicates period of contrast agent infusion. (D) Summary data illustrating volume (mm3) of the brain regions of interest obtained from 3D ROI measurements of contrast-enhanced MR images from sham-operated and BDL animals, with no significant differences reported. Statistical comparisons were performed using 2-way ANOVA followed by Bonferroni post hoc test. p values indicate the level of differences between the sham-operated and BDL groups. BDL, bile duct ligation; CSF, cerebrospinal fluid; HE, hepatic encephalopathy; ROI, region of interest.