Table 3. Effect of the salt substitute on blood pressure according hypertension status at baseline and age groups (sub-group analysis).
Coefficient (95% CI) | p-value | Coefficient (95% CI) | p-value | |
---|---|---|---|---|
Hypertension*** | ||||
Among individuals without hypertension | ||||
Systolic BP | -1.13 (-1.93; -0.33) | 0.006 | -1.15 (-1.96; -0.34) | 0.005 |
Diastolic BP | -0.62 (-1.23; 0.00) | 0.051 | -0.63 (-1.28; 0.01) | 0.053 |
Among individuals with hypertension | ||||
Systolic BP | -1.74 (-3.04; -0.44) | 0.009 | -1.92 (-3.29; -0.54) | 0.006 |
Diastolic BP | -1.25 (-2.24; -0.27) | 0.013 | -1.18 (-2.29; -0.08) | 0.036 |
Age**** | ||||
Among individuals <40 years | ||||
Systolic BP | -0.91 (-1.51; -0.31) | 0.003 | -0.94 (-1.54; -0.34) | 0.002 |
Diastolic BP | -0.25 (-0.79; 0.30) | 0.38 | -0.27 (-0.80; 0.27) | 0.33 |
Among individuals 40-59 years | ||||
Systolic BP | -1.20 (-2.02; -0.38) | 0.004 | -1.17 (-1.98; -0.35) | 0.005 |
Diastolic BP | -1.04 (-1.70; -0.39) | 0.002 | -1.01 (-1.67; -0.36) | 0.002 |
Among individuals ≥60 years | ||||
Systolic BP | -1.95 (-3.44; -0.45) | 0.01 | -2.17 (-3.67; -0.68) | 0.004 |
Diastolic BP | -1.13 (-2.09; -0.18) | 0.02 | -1.18 (-2.14; -0.22) | 0.02 |
Linear mixed effects regression model were used for analyses (n = 2376 biologically independent individuals and 16632 samples in total).
Adjusted for time and clustering, as per study design.
Adjusted by time and clustering, but also by age, sex, education, wealth index, and body mass index. Age was excluded as confounder when analyses were stratified by age.
p-values for the interaction of hypertension status and intervention were 0.858 and 0.951 for the systolic and diastolic BP models.
p-values for the interaction of age groups and intervention were 0.211 and 0.279; and 0.379 and 0.015 for the systolic and diastolic BP models.