Table 3. Effect of the salt substitute on blood pressure according hypertension status at baseline and age groups (sub-group analysis).

Blood pressure levels	Time and cluster adjusted estimates*		Fully adjusted estimates**
	Coefficient (95% CI)	p-value	Coefficient (95% CI)	p-value
Hypertension***
Among individuals without hypertension
Systolic BP	-1.13 (-1.93; -0.33)	0.006	-1.15 (-1.96; -0.34)	0.005
Diastolic BP	-0.62 (-1.23; 0.00)	0.051	-0.63 (-1.28; 0.01)	0.053
Among individuals with hypertension
Systolic BP	-1.74 (-3.04; -0.44)	0.009	-1.92 (-3.29; -0.54)	0.006
Diastolic BP	-1.25 (-2.24; -0.27)	0.013	-1.18 (-2.29; -0.08)	0.036
Age****
Among individuals <40 years
Systolic BP	-0.91 (-1.51; -0.31)	0.003	-0.94 (-1.54; -0.34)	0.002
Diastolic BP	-0.25 (-0.79; 0.30)	0.38	-0.27 (-0.80; 0.27)	0.33
Among individuals 40-59 years
Systolic BP	-1.20 (-2.02; -0.38)	0.004	-1.17 (-1.98; -0.35)	0.005
Diastolic BP	-1.04 (-1.70; -0.39)	0.002	-1.01 (-1.67; -0.36)	0.002
Among individuals ≥60 years
Systolic BP	-1.95 (-3.44; -0.45)	0.01	-2.17 (-3.67; -0.68)	0.004
Diastolic BP	-1.13 (-2.09; -0.18)	0.02	-1.18 (-2.14; -0.22)	0.02

Linear mixed effects regression model were used for analyses (n = 2376 biologically independent individuals and 16632 samples in total).

^*Adjusted for time and clustering, as per study design.

^**Adjusted by time and clustering, but also by age, sex, education, wealth index, and body mass index. Age was excluded as confounder when analyses were stratified by age.

^***p-values for the interaction of hypertension status and intervention were 0.858 and 0.951 for the systolic and diastolic BP models.

^****p-values for the interaction of age groups and intervention were 0.211 and 0.279; and 0.379 and 0.015 for the systolic and diastolic BP models.