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. Author manuscript; available in PMC: 2022 Jul 20.
Published in final edited form as: Mol Cell. 2020 Apr 28;78(5):862–875.e8. doi: 10.1016/j.molcel.2020.04.007

Figure 7. Model of ENRI function.

Figure 7

(A) In the soma, ENRI-1/2 gate NRDE-3 by preventing precocious and inappropriate loading of NRDE-3 with 22G-RNAs produced downstream of the 21U-RNA and/or 26G-RNA pathways. ENRI-1/2 association with NRDE-3 could be regulated by PTMs. (B) We propose that ENRI-1 and ENRI-2 sequester NRDE-3 in the early embryo to prevent loading of 22G-RNAs downstream of germline RNAi pathways. (C) We propose that ENRI-3 gates one or many of the Argonautes acting in the germline and loss of ENRI-3 impacts multiple pathways leading to impaired inheritance of RNAi and activation of transposons.