Table 3. Whole-brain functional connectivity network measures.

The BD group global network organisation did not differ from that of controls across all whole-brain network measures. Specifically, there was no main effect of (a) diagnosis (F(7,86)=1.863, p=0.086), (b) gender (F(7,86)=0.770, p=0.614), or (c) interaction between gender and diagnosis (F(7,86)=1.636, p=0.136) in BD relative to controls. MANCOVA, *p<0.05.

	Healthy Controls (mean±SD)	Bipolar Disorder (mean±SD)	(a) Statistical Comparison Diagnosis (F, p-value)	(b) Statistical Comparison Gender (F, p-value)	(c) Interaction Gender and Diagnosis ((F, p-value)
Positive Strength Male Female	15.44±3.70 14.95±3.84 15.85±3.57	15.93±4.06 16.7±4.42 15.20±3.65	0.52, 0.47	0.12, 0.73	2.07, 0.07
Negative Strength Male Female	2.90±1.24 3.16±1.31 2.69±1.16	3.02±1.06 2.99±0.98 3.05±1.16	0.12, 0.60	0.77, 0.38	0.96, 0.33
Betweenness Centrality Male Female	244.77±19.64 244.88±23.27 244.69±16.55	251.11±22.16 252.28±27.24 250.01±16.55	2.65, 0.11	0.03, 0.86	0.000133, 0.99
Global Efficiency Male Female	0.27±0.04 0.28±0.05 0.27±0.04	0.27±0.04 0.26±0.03 0.27±0.04	0.83, 0.36	1.12, 0.29	3.5, 0.07
Characteristic Path Length Male Female	4.42±0.54 4.48±0.54 4.36±0.54	4.38±0.53 4.27±0.56 4.47±0.5	0.23, 0.63	0.13, 0.72	1.92, 0.17
Clustering Coefficient Male Female	0.17±0.05 0.17±0.05 0.18±0.04	0.18±0.05 0.19±0.05 0.17±0.04	1.04, 0.31	0.29, 0.59	2.56, 0.11
Assortativity Male Females	0.05±0.06 0.05±0.06 0.05±0.06	0.05±0.06 0.05±0.06 0.05±0.06	0.20, 0.89	0.02, 0.89	0.22, 0.64