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. Author manuscript; available in PMC: 2022 Jul 23.
Published in final edited form as: Transplantation. 2019 Oct 1;103(10):2065–2074. doi: 10.1097/TP.0000000000002773

Figure 3.

Figure 3

Interleukin-21 receptor (IL-21R) blockade reduces lymphocyte infiltration in skin grafts. Typical examples of immunohistochemical stainings of human skin grafts for (A) human CD45, (B) human CD3, (C) human CD4, (D) human CD8, and (E) human CD20. Increased infiltration of human lymphocytes was detected in skin of vehicle-treated animals compared to anti-IL-21R antibody (αIL-21R)-treated animals. Quantified data are presented as mean proportions of the positive area with SEM or as mean positive cells counted within the total dermis and epidermis with SEM. Magnification: ×10. Vehicle group n = 7, αIL-21R group n = 8 (*P < 0.05, ***P < 0.001).