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. Author manuscript; available in PMC: 2022 Jul 23.
Published in final edited form as: Neuroimage. 2019 Dec 24;209:116471. doi: 10.1016/j.neuroimage.2019.116471

Table 2. Comparison of the three fibre orientation reconstruction algorithms in vivo.

For each algorithm (tensor, dRL, CSD) and each tissue type (Ctrl, NAWM, T2L, T1l), we calculated voxel-wise averages of the following parameters: the number of streamlines found in a voxel, the average FA/FOD amplitude across all streamlines found in a voxel, the number of streamline terminations due to the amplitude threshold in a voxel, and the number of streamline terminations due to the angle threshold in a voxel. The mean ± SD of these measures across healthy controls (Ctrl; N = 19) and patients (NAWM, T2L, T1L; N = 29 of the MS subgroup) are reported. The values across different tissues types were statistically compared (unpaired t-test between Ctrl vs NAWM tissue; paired t-tests for T2L vs NAWM, and T1L vs T2L) and t and p statistics are provided for each comparison. Acronyms: Ctrl: Control tissue, NAWM: normal appearing white matter, T2L: T2-weighted white matter hyperintense lesional tissue without T1-weighted hypointensity, T1L: T1-weighted white matter hypointense lesional tissue with corresponding T2-weighted hyperintensity.

Ctrl NAWM T2L T1L NAWM vs Ctrl T2L vs NAWM T1L vs T2L
Average number of streamlines per voxel
Tensor 32.31 ± 3.35 30.66 ± 4.23 33.48 ± 6.72 30.77 ± 9.52 t = −1.43, p = .16 t = 2.64, p = .01 t = −1.55, p = .13
dRL 38.14 ± 5.91 39.40 ± 5.09 42.68 ± 8.61 40.41 ± 11.25 t = 0.79, p = .44 t = 2.6, p = .02 t = −1.3, p = .20
CSD 63.37 ± 10.22 66.12 ± 8.77 70.70 ± 13.18 70.69 ± 18.86 t = 0.99, p = .33 t = 2.4, p = .02 t = −0.01, p = .996
Average peak amplitude (FOD amplitude/FA) of all streamlines per voxel
Tensor 0.71 ± 0.03 0.68 ± 0.03 0.67 ± 0.04 0.64 ± 0.06 t = −3.1, p = .003 t = −1.1, p = .29 t = −2.4, p = .03
dRL 0.22 ± 0.02 0.21 ± 0.02 0.21 ± 0.02 0.20 ± 0.03 t = −1.1, p = .29 t = −0.2, p = .99 t = −2.7, p = .01
CSD 0.42 ± 0.04 0.43 ± 0.05 0.43 ± 0.06 0.42 ± 0.06 t = 0.78, p = .44 t = 0.64, p = .53 t = −2.2, p = .04
Average number of streamline terminations due to amplitude threshold
Tensor 0.32 ± 0.01 0.24 ± 0.04 0.51 ± 0.26 0.97 ± 0.47 t = −8.7, p < .0001 t = 5.8, p < .0001 t = 8.5, p < .0001
dRL 0.23 ± 0.01 0.25 ± 0.02 0.36 ± 0.11 0.70 ± 0.33 t = 5.9, p < .0001 t = 5.2, p < .0001 t = 6.9, p < .0001
CSD 0.97 ± 0.03 0.87 ± 0.09 0.81 ± 0.19 0.80 ± 0.28 t = −4.7, p < .0001 t = −1.7, p = .10 t = −0.38, p = .71
Average number of streamline terminations per voxel due to angle threshold
Tensor 0.10 ± 0.01 0.13 ± 0.02 0.16 ± 0.07 0.08 ± 0.07 t = 6.4, p < .0001 t = 2.0, p = .05 t = −6.4, p < .0001
dRL 0.58 ± 0.02 0.71 ± 0.08 0.74 ± 0.20 0.53 ± 0.23 t = 7.2, p < .0001 t = 0.86, p = .39 t = −5.3, p < .0001
CSD 1.37 ± 0.09 1.41 ± 0.12 1.76 ± 0.59 2.04 ± 0.76 t = 1.1, p = .26 t = 3.2, p < .01 t = 2.9, p = .0074