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. Author manuscript; available in PMC: 2022 Jul 23.
Published in final edited form as: Nature. 2021 Apr 26;593(7860):597–601. doi: 10.1038/s41586-021-03536-w

Extended Data Figure. 8. Pharmacological inhibition of METTL3 has no lasting effects on normal haematopoiesis.

Extended Data Figure. 8

a-c) Quantification of LSK (Lin-/Ska1+/c-Kit+) and HSC (LSK/CD150+/CD34-) compartments in bone marrow from WT C57BL/6J mice following 14 consecutive daily treatments with either vehicle or 50 mg/kg STM2457 (mean ± s.d., n=5). d) Blood count results from animal experiments related to a-c. e) Body weight of mice from animal experiments related to a-d (n = 5). Statistical significance was determined by two-tailed Mann–Whitney U test and box plots showing median, IQR and extremes. f) RNA-mass spectrometry quantification of m6A levels on poly-A+-enriched RNA from healthy bone marrow related to the animal experiments a-d, following 14 days of consecutive treatments with either vehicle or 50 mg/kg STM2457 (mean ± s.d., n=5). HSC, hematopoietic stem cells; two-tailed Student’s t-test; n.s., not significant.