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. 2022 Mar 21;2:10280. doi: 10.3389/adar.2022.10280

FIGURE 7.

FIGURE 7

Opioid-induced signaling in AtT20 cells expressing WT-MOPr or MOPrP309R−E310R. (A,B). Concentration response curves for fentanyl (green) and morphine (orange) in a membrane potential assay of AtT20 cells expressing (A) WT-MOPr and (B) the MOPrP309R−E310R double mutant. (C,D). Naloxone reversal of the morphine (1 µM) response in (C) WT-MOPr and (D) MOPrP309R−E310R double mutant expressing cells. (E,F) Naloxone reversal of the fentanyl (20 nM) response in (E) WT-MOPr and (F) MOPrP309R−E310R double mutant expressing cells. All data are shown as mean ± SEM, N = 5–6.