Table 3. LXG toxins encoded in L. monocytogenes strains.
| LXG Toxin | Sequence length (aa) | Predicted function | Probable immunity: function | Occurrence/location |
|---|---|---|---|---|
| Toxin A | 458 | structurally related to colicin Ia: membrane depolarizing? | ImA: polytopic membrane protein | essC5 strains variable region 1 |
| Toxin B | 423 | structurally related to colicin Ia: membrane depolarizing? | ImB: DUF5082 domain protein | essC6 strains variable region 1 |
| Toxin C | 537 | structurally related to colicin Ia: membrane depolarizing? | ImC: unknown | essC7 strains variable region 1 |
| Toxin D | 492 | unknown | ImD: unknown | essC1, essC2, essC3, essC4, essC5, essC6, essC7 strains variable region 2 |
| Toxin E | 493 | unknown | ImE: unknown | essC1, essC2, essC4, essC5 strains variable region 2 |
| Toxin F | 507 | structurally related to Tne2: NADase? | ImF: unknown | essC1, essC2, essC3, essC7 strains variable region 2 |
| Toxin G | 479 | structurally related to colicin D/E5 nuclease domain | ImG: unknown | essC1, essC2, essC3, essC5, essC7 strains variable region 2 |
| Toxin H | 462 | unknown | ImH: DUF1871 family protein | cluster of ABC transporter encoding genes |
| Toxin I | 466 | unknown | ImI: unknown | cluster of ABC transporter encoding genes |
| Toxin J | 435 | structurally related to colicin D/E5 nuclease domain | ImJ: unknown | cluster of ABC transporter encoding genes |
| Toxin K | 436 | unknown | ImK: unknown | cluster of ABC transporter encoding genes |
| Toxin L | 463 | structurally related to colicin D/E5 nuclease domain | ImL: unknown | cluster of ABC transporter encoding genes |
| Toxin M | 468 | structurally related to NAD+ glycohydrolase | ImM: Immunity protein 74; pfam15603 | cluster of ABC transporter encoding genes |
| Toxin N | 478 | EndoU-nuclease | ImN: unknown | cluster of ABC transporter encoding genes |
| Toxin O | 465 | unknown | ImO: unknown | cluster of ABC transporter encoding genes |
| Toxin P | 477 | EndoU-nuclease | ImP: unknown | cluster of ABC transporter encoding genes |
| Toxin Q | 475 | EndoU-nuclease | ImQ: unknown | cluster of ABC transporter encoding genes |
| Toxin R | 490 | EndoU-nuclease | ImR: unknown | cluster of ABC transporter encoding genes |
| Toxin S | 491 | unknown | ImS: unknown | Insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin T | 517 | unknown | ImT: unknown | insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin U | 509 | unknown | ImU: unknown | insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin V | 482 | unknown | ImV: unknown | insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin W | 469 | structurally related to colicin D/E5 nuclease domain | ImW: cysteine-rich CPCC superfamily protein | insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin X | 478 | unknown | ImX: unknown | insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin Y | 551 | structurally related to Legionella effector SdeA | ImY: immunity 70 family protein | insertion between DNA-directed RNA polymerase and transketolase encoding genes |
| Toxin Z | 458 | unknown | ImZ: unknown | insertion between leucine-rich repeat surface protein family BspA and oxetanocin A resistance protein OxrB |
| Toxin α | 470 | Unknown | Imα: unknown | insertion between leucine-rich repeat surface protein family BspA and oxetanocin A resistance protein OxrB |
| Toxin β | 491 | structurally related to the of the toxic C-terminal Tip2 of CdiA from Pseudomonas aeruginosa - hemagglutinin | Imβ: member of the prominin superfamily of membrane proteins | insertion between nitronate monooxygenase and cation-translocating P-type ATPase encoding genes |
| Toxin γ | 433 | unknown | Imγ: unknown | insertion between heme oxygenase IsdG and NUDIX hydrolase encoding genes |
| Toxin δ | 457 | unknown | Im δ : unknown | insertion between heme oxygenase IsdG and NUDIX hydrolase encoding genes |
| Toxin ε | 492 | EndoU-nuclease | Im ε : unknown | insertion between heme oxygenase IsdG and NUDIX hydrolase encoding genes |
| Toxin ζ | 502 | structurally related to TelC - probable lipid II phosphatase | Imζ: unknown | Insertion between effector binding domain-containing protein and DeoR/GlpR transcription factor encoding genes |
| Toxin η | 512 | unknown | Imη: unknown | Insertion between effector binding domain-containing protein and DeoR/GlpR transcription factor encoding genes |
| Toxin θ | 540 | unknown | Imθ: polytopic membrane protein | Insertion between effector binding domain-containing protein and DeoR/GlpR transcription factor encoding genes |
| Toxin λ | 466 | unknown | Imλ: unknown | Insertion between glutamine-hydrolysing GMP synthase and α/ß hydrolase encoding genes* |
| Toxin μ | 481 | unknown | Im μ: unknown | Insertion between glutamine-hydrolysing GMP synthase and α/ß hydrolase encoding genes* |
| Toxin π | 462 | unknown | Im π : unknown | Insertion between glutamine-hydrolysing GMP synthase and α/ß hydrolase encoding genes* |
| Toxin ρ | 514 | structurally related to Legionella effector SdeA | Im ρ: unknown | Insertion between chitinase ChiB and ABC transporter ATP-binding protein encoding genes |
| Toxin σ | 491 | Fic superfamily | Imσ: unknown | Insertion between lytic polysaccharide monooxygenase and TetR/AcrR family regulator encoding genes |
| Toxin ϕ | 485 | unknown | Im ϕ: unknown | Insertion between histidine phosphatase family protein and ATP-dependent RNA helicase DbpA encoding genes |
*
two LXG toxins are often encoded at this locus in a head-to-head arrangement.