Figure 1. Diagram of Huntington’s disease pathogenesis and possible therapeutic targets.

Gray boxes with red border indicate potential therapies. ASO=antisense oligonucleotide. BDNF=brain-derived neurotrophic factor. ER=endoplasmic reticulum. LUBAC=linear ubiquitin chain assembly complex. mHTT=mutant Huntingtin. NMDA=N-methyl-D-aspartate. RNAi=RNA interference. TrkB=tyrosine receptor kinase B. ZFP=Zinc-finger protein. Adapted from Bates et al (2015)² with permission