. Author manuscript; available in PMC: 2022 Aug 3.

Published in final edited form as: N Engl J Med. 2021 Nov 11;385(20):1868–1880. doi: 10.1056/NEJMoa2035790

Table 3.

Candidate Variants Returned for Presentation to the NHS Genomic Medicine Centres per Proband with the Automated Virtual Panel–Based Analysis Pipeline.^*

Variable	All Family Structures (2183 Probands)	Singleton (881 Probands)	Family Duo (343 Probands)	Family Trio (797 Probands)	Larger Family Structure (162 Probands)
Median no. of variants returned after filtering (IQR)^†	221 (49–288)	292 (258–327)	149 (117–213)	29 (17–136)	22 (9–71)
Median no. of variants in virtual panels returned after filtering (IQR)	1 (0–2)	1 (0–2)	1 (0–3)	1 (0–2)	0 (0–1)

Singleton refers to a proband for whom no other family member was recruited, family duo to a parent–proband pair, family trio to both parents and a proband, and family quad to a proband, sibling, and parents.

^†

Filtering is the removal of extremely unlikely candidate variants.