The dark line denotes the conditional plot of an imaging phenotype against birth weight, with other variables (sex, age, sex * age, weight, height, SBP, DBP, current smoking status, alcohol intake, vigorous PA frequency, high cholesterol and diabetes) set to their mean. The grey area denotes the 95% confidence interval. n = 12,169 subjects were analysed with available birth weight information. The p-values were calculated from two-sided t-tests.