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. 2022 Jun 2;28(16):3618–3629. doi: 10.1158/1078-0432.CCR-21-3189

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4. Differential expression of gene signatures in resistant tumors. A, Hierarchical clustering of significantly differentially expressed gene signatures in resistant tumors (N = 24 from 17 patients) compared with matched sensitive tumors (N = 29 from 17 patients) identified through linear mixed models. B, Box plots indicating median score and interquartile range of significant signatures showing elevated signaling pathways in resistant tumors. — Differential expression of gene signatures in resistant tumors. A, Hierarchical clustering of significantly differentially expressed gene signatures in resistant tumors (N = 24 from 17 patients) compared with matched sensitive tumors (N = 29 from 17 patients) identified through linear mixed models. B, Box plots indicating median score and interquartile range of significant signatures showing elevated signaling pathways in resistant tumors.