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. 2022 Jun 2;28(16):3618–3629. doi: 10.1158/1078-0432.CCR-21-3189

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 6. Molecular portraits of a HER2-enriched patient with acquired endocrine resistance. A, Box plots indicating median score and interquartile range of VAF of detected variants stratified by synonymous and nonsynonymous variants. B, Heatmap showing VAF of nonsynonymous variants of Pan-Cancer drivers. C, Heatmap showing gene expression of hormone receptors and key signaling pathways. D, Heatmap showing copy number landscapes of all tumors from the patient. — Molecular portraits of a HER2-enriched patient with acquired endocrine resistance. A, Box plots indicating median score and interquartile range of VAF of detected variants stratified by synonymous and nonsynonymous variants. B, Heatmap showing VAF of nonsynonymous variants of Pan-Cancer drivers. C, Heatmap showing gene expression of hormone receptors and key signaling pathways. D, Heatmap showing copy number landscapes of all tumors from the patient.