Fig. 1. TEP1 diversity and classification.
a, Nucleotide diversity over the TEP1 coding sequence plotted above a schematic representation of the protein domain organization. The dashed box indicates the region chosen for genotyping. b, Congruency of TEP1 allelic segregation based on neighbour-joining comparison of full-length (left) versus TED only (right) amino acid sequences, illustrated by bootstrapped (1,000 iterations) phylogenetic trees (50% cut-off). MG, macroglobulin domain; LNK, linker region; CUB, complement C1r/C1s; ANK, 2-disulfide anchor motif.