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. Author manuscript; available in PMC: 2022 Oct 13.
Published in final edited form as: J Mater Chem B. 2020 Sep 3;8(38):8894–8907. doi: 10.1039/d0tb01546f

Figure 3. Nanogel cross-linking via enzyme-responsive peptides using azide-bi-functionalised peptides via CuAAC.

Figure 3

a) Schematic representation of the cross-linking strategy showing how cross-linking enhances nanogel stability below the LCST. b) DLS traces comparing size distribution of 5a4-based self-assembled (before cross-linking from Fig 1c) and cross-linked nanogels below (dashed line) and above (solid line) the LCST(33 °C for 5a4).c) DLS traces comparing size distribution of 5a4- and 5c1-based cross-linked nanogels at 25 °C (below the LCST).d) Study of long-term stability of cross-linked 5a4- and 5c1-based nanogels in PBS incubated at 37 °C and measured by DLS at 25 °C (open symbols) and 37 °C (closed symbols) at each timepoint (N =1, n = 3).