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Abatacept treatment affects circulating Tfh cell frequency and their phenotype. Circulating CXCR5-expressing CD4 T cells (here called Tfh) can express PD-1, ICOS or both (left). Following abatacept treatment the frequency of circulating Tfh cells is reduced and the Tfh cells that remain show markedly lower expression of ICOS and, to a lesser extent, PD-1 (right).
