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Baseline Tfh profile may help predict clinical response following abatacept treatment. Using a predictive modelling approach, we were able to show that the baseline Tfh profile may help predict an individual’s clinical response following abatacept treatment. Responders were shown to have a higher frequency of CXCR5+ICOS-PD-1-CD4+ T cells (left), while CXCR5+CD4+ T cells expressing both ICOS and PD-1 were more abundant in non-responders (right).
