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. Author manuscript; available in PMC: 2022 Aug 22.
Published in final edited form as: Nature. 2021 Nov 10;599(7885):497–502. doi: 10.1038/s41586-021-04030-z

Extended Data Fig. 3. Structural comparison between Cas12k and CasX.

Extended Data Fig. 3

a, Structural model of Cas12k-sgRNA-target DNA (left) and CasX-sgRNA-target DNA (right, PDB: 6ny222) complexes. The structures were superimposed using secondary structure matching46 of the RuvC domains and are shown in identical orientations. b, Zoom-in views of the tracrRNA-crRNA triplexes.