. Author manuscript; available in PMC: 2022 Aug 22.

Published in final edited form as: Br J Clin Pharmacol. 2020 Jul 5;87(2):622–631. doi: 10.1111/bcp.14429

Table 3. Multivariable adjusted odds ratio of a ≥1g/dL haemoglobin reduction in ACEI/ARB initiators vs. CCB initiators.

Model	Minimally Adjusted^a		Fully Adjusted^b
Observations	146,610		138,684
	Adjusted OR	95% CI	Adjusted OR	95% CI
CCB initiators	Reference		Reference
ACEI/ARB initiators	1.24	[1.21-1.28]	1.15	[1.12-1.19]

Adjusted for forced variables (age, sex and pre-initiation haemoglobin).

Additionally adjusted for co-morbidities (hypertension, ischaemic heart disease, heart failure, diabetes, chronic hypoxic conditions, chronic kidney disease), medications (oral bone marrow suppressing drugs, drugs that can cause bleeding), calendar period and clustering at primary care practice level

OR, odds ratio; CI, confidence interval; ACEI/ARB, ACE inhibitor / angiotensin receptor blocker; CCB, calcium channel blocker