Figure 3. Multidimensional connections of the ‘clock’ to the pathogenesis of fatty liver.

Model representing a global view of how alterations in circadian clock-controlled ‘rhythmic’ functions/pathways and processes could predispose to non-alcoholic fatty liver disease. Knowledge of the mechanisms through which the ‘clock’-system influences all these systems and essential pharmacological parameters, in turn, could be utilized to develop novel chronotherapeutics. Green arrowheads represent activation and red bar-heads represent inhibition. See text for details.