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. 2022 Jul 21;4(8):e556–e565. doi: 10.1016/S2665-9913(22)00180-1

Figure 2.

Figure 2

Genome-wide association results for trigger finger and carpal tunnel syndrome

(A) Summary statistics from trigger finger and carpal tunnel syndrome (derived from Wiberg and colleagues) genome-wide association analyses in European patients from UK Biobank. Independent loci in trigger finger summary statistics are annotated with the single-nucleotide polymorphism (SNP) identifier for the index SNP (lowest p-value) at each locus. (B) Results of gene prioritisation analysis for trigger finger trait, using multiple annotations including nearest gene to SNP, cis-eQTL associations and the Variant2Gene score from OpenTargets Genetics. AARS=alanyl-tRNA synthetase. CENPK=centromere protein K. CLEC18A=C-Type Lectin Domain Family 18 Member A. CLEC18C=C-Type Lectin Domain Family 18 Member C. CTSW=cathepsin W. DIRC3=Disrupted In Renal Carcinoma 3. EHBP1L1=EH domain binding protein 1 like 1. FTO=FTO alpha-ketoglutarate dependent dioxygenase. LTBP3=latent transforming growth factor beta binding protein 3. MAP3K=mitogen-activated protein kinase kinase kinase 1. NEAT1=nuclear paraspeckle assembly transcript 1. NEAT5=nuclear paraspeckle assembly transcript 5. NQO1=NAD(P)H quinone dehydrogenase 1. RBL2=RB transcriptional corepressor like 2. RNASEH2C=ribonuclease H2 subunit C. SCYL1=SCY1 like pseudokinase 1. SGTB=small glutamine rich tetratricopeptide repeat co-chaperone beta. TMED6=transmembrane p24 trafficking protein 6. WWP2=WW domain containing E3 ubiquitin protein ligase 2. *Signal at DIRC3 locus common to trigger finger and carpal tunnel syndrome analyses.