Table 1. Summary of included studies for the quantitative analysis.
Study design | Country | Inadvertent treatment | Concomitant albendazole | Gestational period | Spontaneous abortions and stillbirths | Congenital anomalies | |||
---|---|---|---|---|---|---|---|---|---|
Ivermectin-exposed group | Control group | Ivermectin-exposed group | Control group | ||||||
Chippaux et al (1993)32 | Retrospective case-control study | Cameroon | Yes, during MDA programme | No | First trimester* | 21/111 | 53/404 | 0/111 | 2/404 |
Doumbo et al (1992)33 | Retrospective case-control study | Mali | Yes, during MDA programme | No | Unclear | 3/82 | 6/139 | 0/82 | 1/139 |
Gyapong et al (2003)34 | Retrospective case-control study | Ghana | Yes, during MDA programme | Yes | Unclear | 2/50 | 21/293 | 1/50 | 5/293 |
Makene et al (2003)35 | Retrospective case-control study | Tanzania | Yes, during MDA programme | Yes | Unclear | NA | NA | 6/54 | 4/63 |
Ndyomugyenyi et al (2008)36 | Open-label randomised controlled trial | Uganda | No | Yes | Second and third trimester | 4/399 | 7/438 | 1/399 | 1/438 |
Pacque et al (1990)13 | Retrospective case-control study | Liberia | Yes, during MDA programme | No | Unclear | 5/203 | 55/1767 | 5/203 | 21/1767 |
Data are n/N, unless otherwise specified. MDA=mass drug administration. NA=not available. *97 of 110 were exposed during the first trimester of pregnancy; the remaining 13 were not specified. These 110 exposures generated 111 pregnancy outcomes.