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. Author manuscript; available in PMC: 2023 Jan 14.
Published in final edited form as: Nat Rev Dis Primers. 2022 Jul 14;8(1):48. doi: 10.1038/s41572-022-00376-4
Global research priorities on Multimorbidity, as per Academy of Medical Sciences Report46 Research priorities on multimorbidity sensitive to low- and middle-income countries (LMICs) contexts
Research priority 1: What are the trends and patterns in multimorbidity? Research agenda to address multimorbidity in LMICs should be sensitive to existing capacities. In the same way in which LMICs differ from HICs, they also differ from each other, and context-specific data are essential. Hence, a common definition of multimorbidity, including a few physical and mental chronic conditions is essential to advance the research agenda in LMICs. Many LMICs do not have electronic medical records or national surveys for non-communicable diseases, hence a gradual step to data generation is required. A common definition of multimorbidity would allow basic estimates of a few conditions and, as country progresses, more conditions can be added whilst maintaining comparability with previous rounds of data collection.
Research priority 2: Which multimorbidity clusters cause the greatest burden?
Research priority 3: What are the determinants of the most common clusters of conditions?
Research priority 4: What strategies are best able to facilitate the simultaneous or stepwise prevention of chronic conditions that contribute to the most common multimorbidity clusters? Evidence about co-occurring conditions and which combinations most affect health should be generated and aligned with context-specific disease burdens and the capacity of the health system to respond to them.
Research priority 5: What strategies are best able to maximise the benefits and limit the risks of treatment among patients with multimorbidity?
Research priority 6: How can healthcare systems be better organised to maximise the benefits and limit the risks for patients with multimorbidity? As common set of high-quality health systems indicators, placing emphasis on what matters most to people, such as competent care, user experience, health outcomes, and confidence in the system, in addition to other common outcomes, is essential to advance a context-specific agenda for multimorbidity.