Table 1. Routine and specialized haemostatic parameters by experimental group at selected time points.
| Saline only | Endotoxemia only | Endotoxemia + resuscitation | |||||
|---|---|---|---|---|---|---|---|
| Mean (±SEM) | Baseline | 6HR | 12HR | 6HR | 12HR | 6HR | 12HR |
| Full blood examination | |||||||
| WCC (x109/L) | 7.5 (0.36) | 3.0 (0.3) | 3.0 (0.7) | 3.7 (0.4) | 4.6 (0.8) | 3.5 (0.7) | 3.7 (0.8) |
| Hb (g/L) | 95 (3) | 77 (5) | 85 (6) | 89 (7) | 86 (6)a | 97 (7) | 90 (8)a |
| Plt (x109/L) | 351 (38) | 282 (36) | 312 (42) | 162 (27) | 125 (26)a | 120 (20) | 91 (12)a |
| Routine coagulation tests | |||||||
| PT (s) | 13 (0.3) | 21.6 (1.1) | 25.4 (1.5) | 24.9 (1.2) | 34.3 (1.7) | 31.5 (1.7) | 52 (4.6)b |
| aPTT (s) | 29 (1.5) | 38 (3) | 42 (3) | 42 (3) | 52 (5) | 51 (5) | 75 (11)b |
| Fibrinogen (g/L) | 1.7 (0.1) | 1.3 (0.02) | 1.4 (0.04) | 0.6 (0.1) | 0.4 (0.1)a | 0.5 (0.03) | 0.4 (0.01)a |
| Specialized coagulation tests | |||||||
| Protein C (U/mL) | 0.55 (0.02) | 0.42 (0.05) | 0.36 (0.04) | 0.25 (0.02) | 0.20 (0.01)a | 0.18 (0.03) | 0.11 (0.02)a,b |
| Protein S (free) (U/mL) | 1.85 (0.03) | 1.15 (0.06) | 1.07 (0.08) | 1 (0.03) | 0.81 (0.05) | 0.86 (0.09) | 0.56 (0.08) |
| AT (U/mL) | 0.91 (0.03) | 0.55 (0.03) | 0.5 (0.04) | 0.5 (0.03) | 0.42 (0.02) | 0.4 (0.02) | 0.24 (0.04)b |
| FV (U/mL) | 5.01 (0.27) | 4.59 (0.25) | 4.92 (0.2) | 3.14 (0.24) | 2.42 (0.26)a | 2.77 (0.31) | 1.6 (0.25)a |
| FVII (U/mL) | 0.13 (0.01) | 0.06 (0.004) | 0.05 (0.004) | 0.05 (0.004) | 0.03 (0.003) | 0.05 (0.01) | 0.03 (0.004) |
| FVIII (U/mL) | 6.70 (0.28) | 5.08 (0.41) | 5.02 (0.29) | 2.41 (0.41) | 2.39 (0.42)a | 2.17 (0.33) | 1.83 (0.32)a |
| FX (U/mL) | 0.12 (0.02) | 0.06 (0.004) | 0.05 (0.003) | 0.05 (0.003) | 0.04 (0.003)a | 0.02 (0.002) | 0.02 (0.01)a |
ap < 0.05 compared with saline only
bp < 0.05 compared with endotoxemia only. aPTT indicates activated partial thromboplastin time; AT, antithrombin; Hb, haemoglobin; Plt, Platelet; PT, prothrombin time; WCC, white cell count.