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. Author manuscript; available in PMC: 2022 Sep 15.
Published in final edited form as: Proc Nutr Soc. 2021 Mar 5;80(3):356–364. doi: 10.1017/S0029665121000550

Table 1. Criteria used in developing dietary reference values for 11 micronutrients: adults and children.

United Kingdoma US/Canadab European Unionc Factord
Adults
Avoidance of risk of deficiency (clinical signs, biomarker threshold) B12, C, D* riboflavin, B12, C, D riboflavin, folate, B12, D x
Factorial method: (retention/turnover+obligatory losses) A, iron, calcium, potassium, A, iron A, C, iron body size
Balance/depletion-repletion studies (using biomarkers, energy intake) folate, magnesium, thiamin, folate, calcium magnesium thiamin, calcium body size
Usual intake or biomarker status riboflavin potassium magnesium body size
Intake of energy/protein thiamin body size
Optimisation of function/health (other than frank deficiency) potassium x
Children
Interpolation: infant breastmilk intake and adult value (using reference weights) A, riboflavin, folate, B12, C, iron, magnesium C C body size
Extrapolation: adult values (using reference weights or metabolic weight*growth factor) A, thiamin, riboflavin, folate, B12, magnesium riboflavin, folate, B12, potassium body size
Extrapolation: from adult value (using energy/protein intake) thiamin thiamin body size
Factorial method: (retention/turnover+obligatory losses) calcium, potassium iron, calcium A, iron, calcium body size
Usual intake potassium magnesium body size
Same value as adults D* D D x
a

Developed and published by the Committee on the Medical Aspects of Food Policy1991(2), unless otherwise stated

b

Developed and published by the Institute of Medicine in a series 1997-2001(47), unless otherwise stated

c

Developed and published by the European Food Safety Authority in a series 2013-2017(10)

d

Indicates whether body size is an intrinsic factor of the criterion

*

Published by the Scientific Advisory Committee on Nutrition 2016(3)

Developed and published by the Institute of Medicine 2011(8)

Developed and published by the National Academies of Sciences, Engineering, and Medicine 2019(9)