Table 1. Criteria used in developing dietary reference values for 11 micronutrients: adults and children.
United Kingdoma | US/Canadab | European Unionc | Factord | |
---|---|---|---|---|
Adults | ||||
Avoidance of risk of deficiency (clinical signs, biomarker threshold) | B12, C, D* | riboflavin, B12, C, D† | riboflavin, folate, B12, D | x |
Factorial method: (retention/turnover+obligatory losses) | A, iron, calcium, potassium, | A, iron | A, C, iron | body size |
Balance/depletion-repletion studies (using biomarkers, energy intake) | folate, magnesium, | thiamin, folate, calcium† magnesium | thiamin, calcium | body size |
Usual intake or biomarker status | riboflavin | potassium‡ | magnesium | body size |
Intake of energy/protein | thiamin | body size | ||
Optimisation of function/health (other than frank deficiency) | potassium | x | ||
Children | ||||
Interpolation: infant breastmilk intake and adult value (using reference weights) | A, riboflavin, folate, B12, C, iron, magnesium | C | C | body size |
Extrapolation: adult values (using reference weights or metabolic weight*growth factor) | A, thiamin, riboflavin, folate, B12, magnesium | riboflavin, folate, B12, potassium | body size | |
Extrapolation: from adult value (using energy/protein intake) | thiamin | thiamin | body size | |
Factorial method: (retention/turnover+obligatory losses) | calcium, potassium | iron, calcium† | A, iron, calcium | body size |
Usual intake | potassium‡ | magnesium | body size | |
Same value as adults | D* | D† | D | x |
Developed and published by the Committee on the Medical Aspects of Food Policy1991(2), unless otherwise stated
Developed and published by the Institute of Medicine in a series 1997-2001(4–7), unless otherwise stated
Developed and published by the European Food Safety Authority in a series 2013-2017(10)
Indicates whether body size is an intrinsic factor of the criterion
Published by the Scientific Advisory Committee on Nutrition 2016(3)
Developed and published by the Institute of Medicine 2011(8)
Developed and published by the National Academies of Sciences, Engineering, and Medicine 2019(9)