Table 3.

Pro-fibrosis role of autophagy in lung fibrosis.

Pro-fibrostic roles of autophagy in lung fibrosis	Reference
SiO2-induced macrophage autophagy promoted proliferation and migration of fibroblasts.	Liu et al (2016, 2017)82,111
Autophagy upregulated in SiO2 induced lung fibrosis. In lung fibroblasts, SiO2 downregulated circRNA-012091 and induced up-regulation of downstream PPP1R13B. PPP1R13B regulates migration and proliferation of fibroblasts via ER stress and autophagy.	Cheng et al (2019)65
Serum starved fibroblasts with autophagy induced increased myofibroblast markers.	Bernard et al (2014)88
Inducing autophagy by deletion of Golgin A2 (GOLGA2), induced lung fibrosis.	Park et al (2018)97
Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls, mediated by autophagy.	Krempaska et al (2020)76
Alveolar macrophages from Park2−/− mice demonstrated increased apoptosis compared to BLM-injured WT mice	Larson-Casey et al (2016)81