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. 2022 Apr 16;226(5):920–927. doi: 10.1093/infdis/jiac144

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© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Temporal changes in complexity of infection (COI) across asymptomatic and first febrile infections. The figure shows the distribution of mean COI based on ama1 over time in asymptomatic (A) and febrile (B) infections. The gray circles are the COI for the individuals genotyped, while the black diamonds are the mean COI per timepoint. The numbers above each time point represent the expected ama1 heterozygosity. The graphs do not include samples beyond 2010 for asymptomatic infections and 2011 for febrile infections, since the samples were specifically selected as asymptomatic–febrile pairs, reducing the sample size to <10.