Table 1. Patient characteristics across four studies.
For age, parasite densities, platelet counts, total white blood cell counts, and PfHRP2 concentrations, we show the median values with IQRs in parentheses. No HbS genotyping was done for Bangladeshi patients, because HbS is absent in this population.
| Kilifi (Kenya) | Kampala (Uganda) | FEAST (Uganda) | Bangladesh | |
|---|---|---|---|---|
| n | 1400 | 492 | 559 | 171 |
| Age (years, IQR) | 2.4 (1.4–3.7) | 3.3 (2.2–4.6) | 2.0 (1.2–3.3) | 30 (23–45) |
| Proportion parasite positive (%) | 100 | 100 | 59.4 | 100 |
| Parasite density * (per μl, IQR) | 69,824 (6099–316,350) | 42,530 (10,635–198,540) | 37,600 (3640–153,680) | 148,874 (23,550–348,540) |
| Platelet count (×103/μl, IQR) | 111 (64–215) | 96 (49–170) | 165 (75–326) | 50 (27–139) |
| PfHRP2 (ng/ml, IQR) | 2207 (419–5072) | 1838 (588–4097) | 175 (0–1953) | 2667 (1083–6128) |
| White blood cell count (/μl, IQR) | 12.6 (8.9–19) | 10.4 (7.5–15.3) | 12.0 (8.4–18.7) | 9.0 (6.9–11.0) |
| Mortality (%) | 11.1 | 6.7 | 11.4 | 26.9 |
| HbAS (n, %) | 41 (2.9) | 4 (0.8) | 46 (8.2) | – |
| HbSS (n, %) | 7 (0.5) | 23 (4.7) | 21 (3.8) | – |
*
For the FEAST trial, parasite densities refer only to patients with a positive rapid diagnostic test.