Table 1. Genetic instruments for coffee and caffeine consumption.
| SNP | Chr | Pos (hg_37) | Nearby gene | EA | NEA | EAF | Beta | SE | P value |
|---|---|---|---|---|---|---|---|---|---|
| Coffee Consumption | |||||||||
| rs574367 | 1 | 177873210 | SEC16B | T | G | 0.21 | 0.021 | 0.004 | 8.06E-09 |
| rs10865548 | 2 | 631606 | TMEM18 | G | A | 0.83 | 0.031 | 0.004 | 4.46E-15 |
| rs1260326 | 2 | 27730940 | GCKR | C | T | 0.61 | 0.027 | 0.003 | 2.62E-19 |
| rs1057868 | 7 | 75615006 | POR | T | C | 0.29 | 0.039 | 0.003 | 5.26E-33 |
| rs34060476 | 7 | 73037956 | MLXIPL | G | A | 0.13 | 0.038 | 0.004 | 5.06E-18 |
| rs4410790 | 7 | 17284577 | AHR | C | T | 0.63 | 0.079 | 0.003 | 5.59E-141 |
| rs73073176 | 7 | 17562952 | LOC101927630 | C | T | 0.87 | 0.046 | 0.004 | 5.56E-25 |
| rs597045 | 11 | 56272114 | 0R8U8 | A | T | 0.69 | 0.021 | 0.003 | 6.62E-11 |
| rs1956218 | 14 | 33075243 | AKAP6 | G | A | 0.56 | 0.016 | 0.003 | 3.62E-08 |
| rs2472297 | 15 | 75027880 | CYP1A1/2 | T | C | 0.27 | 0.091 | 0.003 | 5.19E-155 |
| rs66723169 | 18 | 57808978 | MC4R | A | C | 0.23 | 0.029 | 0.004 | 9.88E-17 |
| rs2330783 | 22 | 24747031 | SPECC1L-ADORA2A | G | T | 0.99 | 0.091 | 0.013 | 1.57E-12 |
| Caffeine Consumption | |||||||||
| rs4410790 | 7 | 17244953 | AHR | C | T | 0.62 | 0.150 | 0.017 | 2.36E-19 |
| rs2470893 | 15 | 74727108 | CYP1A1 | T | C | 0.31 | 0.120 | 0.016 | 5.15E-14 |
Chr, chromosome; EA, effect allele; EAF, effect allele frequency; NEA, non-effect allele; Pos, position; SNP, single nucleotide polymorphism. Beta and SE were scaled to 50% increase in coffee consumption.