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. Author manuscript; available in PMC: 2023 Jan 26.
Published in final edited form as: Nat Cancer. 2022 Jul 26;3(7):793–807. doi: 10.1038/s43018-022-00411-z

Figure 3. scRNA-seq reveals multiple tasks undertaken by discrete CAF subtypes.

Figure 3

The major tasks performed by the three central CAF subtypes-ECM reorganization, immune regulation, and antigen presentation, are mediated through expression of various cell surface receptors and secreted factors that influence tumor progression. The secreted factors and receptors listed in the figure generally vary according to disease type and organ, and are designated accordingly in Figure 4. The figure was created with BioRender.com.