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. Author manuscript; available in PMC: 2022 Oct 5.
Published in final edited form as: Cancer Res. 2022 Oct 4;82(19):3435–3448. doi: 10.1158/0008-5472.CAN-22-0325

Figure 4. KPAR orthotopic tumours generate an adaptive immune response.

Figure 4

(A) Immune profile of KPAR and KPB6 orthotopic tumours compared to normal lung, assessed by flow cytometry.

(B) Frequency of tumour-infiltrating T cell populations and NK cells.

(C) Percentage of effector memory CD8+ (left) and CD4+ (right) T cells.

(D) Quantification of PD-1, LAG-3 and TIM-3 expression on CD8+ (left) and CD4+ (right) T cells.

(E) Representative plot of PD-1 and LAG-3 expression on CD8+ T cells.

(F) Frequency of PDL1+ macrophages, cDC1, cDC2, monocytes and neutrophils. Tumours were analysed 21 days after transplantation. In (B)-(D) and (F), data are mean ± SEM, n=4 mice (KPB6) or 9 mice (KPAR), symbols represent pooled tumours from individual mice. Unpaired, two-tailed Student’s t-test; ns P>0.05, * P≤0.05, ** P≤0.01, *** P≤0.001, **** P≤0.0001.