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. Author manuscript; available in PMC: 2022 Oct 11.
Published in final edited form as: Mol Cell. 2022 Aug 25;82(17):3178–3192.e5. doi: 10.1016/j.molcel.2022.08.001

Figure 1. Crystal structure of the Cas13bt3-crRNA binary complex.

Figure 1

(A) Domain structure of Cas13bt3. IDL1, inter-domain linker 1; IDL2, inter-domain linker 2.

(B) Diagram of the crRNA used for crystallization.

(C and D) Ribbon (C) and surface (D) representations of the Cas13bt3-crRNA complex. In (C), disordered regions are indicated as dotted lines.

(E) Structure of the PbuCas13b-crRNA complex (PDB: 4DTD). The PbuCas13b-specific insertions (Ins1–10) are highlighted in blue.