. Author manuscript; available in PMC: 2022 Oct 13.

Published in final edited form as: J Control Release. 2022 Sep 22;351:137–150. doi: 10.1016/j.jconrel.2022.09.021

Table 2.

Microparticle characteristics of spray dried LNP formulations in 5% lactose solution at an outlet temperature of 62 °C using a Next Generation Impactor (NGI). DD: dose delivered, FPD: fine particle dose, FPF: fine particle fraction, MMAD: mass median aerodynamic diameter, GSD: geometric standard deviation.

	nLNP	(±)LNP	(-)LNP
DD (μg)	2.37 ± 0.85	2.62 ± 0.31	2.66 ± 0.70
FPD (μg)	0.70 ± 0.27	0.74 ± 0.13	0.73 ± 0.10
FPF (%)	29.5 ± 0.60	28.1 ± 1.70	28.1 ± 3.80
MMAD (μm)	2.85 ± 0.07	2.85 ± 0.35	2.90 ± 0.42
GSD (μm)	1.96 ± 0.02	2.01 ± 0.05	2.01 ± 0.16
Recovery (%)	71.1 ± 28.1	82.9 ± 4.50	86.8 ± 17.3