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. Author manuscript; available in PMC: 2022 Oct 20.
Published in final edited form as: Nat Struct Mol Biol. 2022 Sep 12;29(9):891–897. doi: 10.1038/s41594-022-00821-8

Extended Data Figure 2. Virtual 4C following auxin mediated degradation of CTCF and SCC1.

Extended Data Figure 2

Virtual 4C plots obtained by extracting Hi-C interactions using the Shh promoter as a viewpoint (grey dashed line) from untreated (- auxin) and treated (+ auxin) (a) CTCF-AID mESCs (data are from ref 6) or (b) SCC1-AID mESCs (data are from ref 25). Gene track is shown above and yellow dashed lines indicate the position of enhancers SBE6, SBE2 and ZRS. The lowest panel shows a subtraction of untreated and treated cells with gain of interactions indicated in red and loss of interactions indicated in blue.